Cancer Type: Lung_adenocarcinoma(TCGA,US)
The Cancer Summary network presents the relationships between driver genes and miRNA drivers in a specific cancer type. The resources of gene dataset include the Cancer Gene Census (GCG) and the Network of Cancer Genes (NGC6.0). Driver genes possess various features and are denoted by nodes gridded with colors (as shown in the legend figure); miRNA drivers are denoted by yellow nodes. These nodes are connected by lines to show the protein-protein interactions (PPIs) in the STRING database and synergistic effects, defining by which hazard ratio (HR) of two genes is greater than 1.5 fold of each gene. Also, the interactions of miRNAs and genes are recorded in miRTarBase.
Note: The nodes without any connection would be removed.
The Functional Annotation section provides 3 levels of functional analysis of driver genes: Gene Oncology, Pathways, and Protein/Genetics interactions.
The Gene Ontology (GO) describes our knowledge of the biological domain. GO categories and genes are divided into three groups: biological process, cellular component, and molecular function.
The Pathway section includes 12 collections of gene sets sourced from 7 public databases:
KEGG, Recatome, PID, Biocarta, MsigDB, miRTar, and miRWalk.
Note: Only the top 30 pathways and their corresponding genes are shown below.
The Protein/Genetic interaction section provides a network of how proteins and genes interact with each other, and it lays out from 3 databases: BioGRID, IntAct and STRING.